Clinical Trial: Effects of Chronic Use of Doxazosin in Men With Benign Prostatic Hyperplasia
Study Status: Completed
Recruit Status: Completed
Study Type: Interventional
Official Title: A Prospective Study for the Effects of Chronic Use of Doxazosin on Alpha 1-adrenergic Receptors in Men With Benign Prostatic Hyperplasia
Brief Summary: In this study, we investigate the changes of the expression of alpha adrenergic receptor in the prostate tissue during 2-yr medication period in the man with benign prostatic hyperplasia. And we also evaluate the efficacy and safety of 24 mo-treatment with doxazosin (4mg, 8mg)
Detailed Summary:
To compare the expression of alpha-1 adrenergic receptors, we will use various methodologies such as
- Real-time RT-PCR
- Radioligand receptor binding
- Western blot
- Immunohistochemistry
Sponsor: Samsung Medical Center
Current Primary Outcome: Expression of alpha-1 adrenoceptor [ Time Frame: before treatment and 12mos and 24 mos after treatment ]
Original Primary Outcome: Same as current
Current Secondary Outcome: International Prostate Symptom Score, Patient perception of bladder condition, Maximal flow rate of urine, Postvoid Residual, Prostate volume, Serum PSA level, Adverse events [ Time Frame: before treatment and 3mos, 12mos, and 24mos after treatment ]
Original Secondary Outcome: International Prostate Symptom Score, Patient perception of bladder condition, Maximal flow rate of urine, Postvoid Residual, Prostate volume, Serum PSA level, Advers events [ Time Frame: before treatment and 3mos, 12mos, and 24mos after treatment ]
Information By: Samsung Medical Center
Dates:
Date Received: August 7, 2008
Date Started: January 2007
Date Completion:
Last Updated: August 25, 2010
Last Verified: August 2010
