Clinical Trial: Therapeutic Antibodies Against Prion Diseases From PRNP Mutation Carriers

Study Status: Recruiting
Recruit Status: Recruiting
Study Type: Observational [Patient Registry]

Official Title: Therapeutic Antibodies Against Prion Diseases From PRNP Mutation Carriers

Brief Summary: The human Prion diseases can be classified into sporadic, acquired and inherited forms. Inherited forms usually manifest in higher age so there have to be factors preventing Prion propagation in young mutation carriers. Antibodies against the flexible tail of Prions have been shown to be protective in mice. The investigators intend to screen mutation carriers and controls for the presence of Prion autoantibodies.

Detailed Summary:
Sponsor: University of Zurich

Current Primary Outcome: Anti-Prion protein autoantibody levels [ Time Frame: Baseline, up to 90 years ]

Original Primary Outcome: Same as current

Current Secondary Outcome:

Original Secondary Outcome:

Information By: University of Zurich

Dates:
Date Received: July 7, 2016
Date Started: September 2015
Date Completion:
Last Updated: July 14, 2016
Last Verified: July 2016