Clinical Trial: Genetic Study of Age Related Hearing Loss

Study Status: Completed
Recruit Status: Completed
Study Type: Interventional

Official Title: Genetic Study of Age Related Hearing Loss

Brief Summary:

Age-related hearing loss, or presbyacusis, is one of the most common chronically handicapped conditions for the elderly. Many factors including genetics, diet, diseases, drugs, socioeconomic factors and environmental variables were considered to be related to the development of presbyacusis. Evidences have shown that genetic factors play an important role on presbyacusis. However, which genes or their genotypes are associated with presbycusis remain unknown.

The aim of this project was to evaluate the association between the genotype of candidate genes and presbyacusis by cross-section and case-control study. In the first stage, the investigators plan to select 700 healthy subjects older than 50 with symmetric, sensorineural hearing loss. The subjects will receive basic otologic examination, pure tone audiometry, questionnaire, and genotype analysis. Because gender and age would affect hearing loss significantly, The investigators will convert the hearing level of all subjects into a gender and age independent Z-score according to ISO 7029 standard. And, The investigators define subjects within higher 30 % of Z-score as the presbyacusis group, and subjects within lower 30% of Z-score as the control group. Finally, The investigators perform Chi square analysis to test the association between genotype of candidate genes or their combinations in both groups, and calculate the odds ratio for presbyacusis between different genotype of candidate genes. Further more, we will evaluate the effect of genotype of candidate genes, environment factors, and gene-environmental interaction on the severity of presbyacusis by multivariate logistic regression.

In the second stage, The investigators wish to know the pattern of genotype and hearing level in the high risk families, according to results from the first stage, by description and c

Detailed Summary:
Sponsor: National Taiwan University Hospital

Current Primary Outcome: which gene or Single nucleotide polymorphism is related to age related hearing loss [ Time Frame: 2008-2009 ]

Original Primary Outcome: Same as current

Current Secondary Outcome: Which environmental factor(s) or systemic diseases are related to age related hearing loss [ Time Frame: 2008-2009 ]

Original Secondary Outcome: Same as current

Information By: National Taiwan University Hospital

Dates:
Date Received: September 1, 2008
Date Started: August 2008
Date Completion:
Last Updated: November 21, 2012
Last Verified: November 2012