Clinical Trial: Biomarkers of Ovarian Reserve and Correlation With IVF Treatments

Study Status: Completed
Recruit Status: Completed
Study Type: Observational

Official Title: Predictors of Ovarian Response in Women Undergoing Ovarian Stimulation for IVF

Brief Summary: Retrospective study to evaluate the correlation between AFC, FSHb, AMH and IVF outcomes of 347 cycles performed with three different protocols.

Detailed Summary: 347 IVF cycles (236 patients) analyzed for a retrospective study to evaluate the correlation between the biomarkers of ovarian reserve (antral follicles count, antimullerian hormone, basal follicle stimulating hormone) and number of oocytes and mature oocytes (MII) retrieved during the pick up. For the stimulation were used three different protocols: long luteal, antagonist with daily administration of gonadotropins and antagonist with depot administration of gonadotropins.
Sponsor: U.O.S. Procreazione Medicalmente Assistita e Congelamento Gameti

Current Primary Outcome: number of total and mature (MII) oocytes [ Time Frame: 10 months ]

the number of total and mature (MII) oocytes retrieved during the pick up.


Original Primary Outcome: Same as current

Current Secondary Outcome:

  • duration of stimulation [ Time Frame: 10 months ]
    the number of days since the administration of rFSH o corifollitropina alfa until the administration of hCG
  • ovarian sensitivity index or OSI [ Time Frame: 10 months ]
    OSI was calculated dividing the total administered FSH dose by the number of retrieved oocytes
  • pregnancy rate [ Time Frame: 10 months ]
    the number of positive pregnancy tests with the evidence of an embyo with cardiac activity.


Original Secondary Outcome: Same as current

Information By: U.O.S. Procreazione Medicalmente Assistita e Congelamento Gameti

Dates:
Date Received: April 27, 2015
Date Started: February 2014
Date Completion:
Last Updated: May 8, 2015
Last Verified: May 2015