Clinical Trial: Physical Exercise and Ketone Production in Women With or Without Prediabetes

Study Status: Recruiting
Recruit Status: Recruiting
Study Type: Interventional

Official Title: Stimulating the Production of Ketones Through the Combined Use of Physical Exercise and Dietary a Medium Chain Triglycerides (MCT) Supplement

Brief Summary: The aim of this study is to compare the effect on ketone production of dietary an MCT supplement combined or not with physical exercise in two groups of women (N=10/group), healthy adults and patients with prediabetes. After an evaluation of the metabolism (a 4-hour visit with multiple blood samples) at the beginning of the study, all the participants are taken for one-week the MCT supplement alone follow by a one-week period of taking the MCT supplement in combination with physical exercise. At the end of each period of time, the 4-hour visit for the evaluation of the metabolism is repeated.

Detailed Summary:
Sponsor: Université de Sherbrooke

Current Primary Outcome: Plasma ketone concentrations [ Time Frame: 5 days ]

Acetoacetate (uM) and beta-hydroxybutyrate (uM)


Original Primary Outcome: Same as current

Current Secondary Outcome:

  • Plasma glucose concentrations [ Time Frame: 5 days ]
    Glucose (mM)
  • Plasma cholesterol concentrations [ Time Frame: 5 days ]
    Total cholesterol (mM)
  • Plasma triglyceride concentrations [ Time Frame: 5 days ]
    Triglycerides (mM)
  • Plasma free fatty acid concentrations [ Time Frame: 5 days ]
    Free fatty acids (mM)
  • Plasma insulin concentrations [ Time Frame: 5 days ]
    Insulin (IU/L)


Original Secondary Outcome: Same as current

Information By: Université de Sherbrooke

Dates:
Date Received: February 5, 2016
Date Started: September 2015
Date Completion: March 2018
Last Updated: March 27, 2017
Last Verified: May 2016