Clinical Trial: Effect of Resistance Training on Metabolic Control and Outcome in Prediabetes (NMR-based Metabonomics)

Study Status: Recruiting
Recruit Status: Recruiting
Study Type: Interventional

Official Title: Effect of Resistance Training on Metabolic Control and Outcome in Prediabetes (NMR-based Metabonomics)

Brief Summary: This study evaluates the efficacy of a 12-month resistance training on metabolic control and reducing the risk of diabetes.

Detailed Summary: Most of exercise interventions involved aerobic exercises, investigators were not able to find a single long term study focusing on type 2 diabetes prevention with resistance training and aerobic exercise. It has been known that for those who have already had diabetes, resistance training can reduce insulin resistance and HbA1c level, improve lipid profile, and decrease blood pressure. Based on previous findings, investigators will evaluate how the different exercising interventions impact on insulin resistance, metabolic control, and the incidence and prevalence of diabetes in prediabetes population who receive 12 months of either resistant training or aerobic exercise. Further more, metabolomics approach will be introduced to detect biological markers,and therefore,to analyze the predictive values of metabolomics on long term outcomes of prediabetes population.
Sponsor: Nanjing University of Traditional Chinese Medicine

Current Primary Outcome:

  • glycemic control [ Time Frame: 6 months ]
    Fasting blood glucose, postprandial blood glucose and HbA1c will be measured at 6 months.
  • glycemic control [ Time Frame: 12 months ]
    Fasting blood glucose, postprandial blood glucose and HbA1c will be measured at 12 months.


Original Primary Outcome:

  • Change from baseline glycemic control at 6 months [ Time Frame: 6 months ]
    Fasting blood glucose, postprandial blood glucose and HbA1c will be measured.
  • Change from 6 months glycemic control at 12 months [ Time Frame: 12 months ]
    Fasting blood glucose, postprandial blood glucose and HbA1c will be measured.


Current Secondary Outcome:

  • small molecule metabolites [ Time Frame: 6 months ]
    Biological markers, with the method of metabolomics approach, will be measured at 6 months
  • small molecule metabolites [ Time Frame: 12 months ]
    Biological markers, with the method of metabolomics approach, will be measured at 12 months.
  • Incidence rate of diabetes [ Time Frame: 6 months ]
    Evaluate the incidence of diabetes in prediabetes population at 6 months.
  • Incidence rate of diabetes [ Time Frame: 12 months ]
    Evaluate the incidence of diabetes in prediabetes population at 12 months.


Original Secondary Outcome:

  • small molecule metabolites [ Time Frame: 6 months ]
    Biological markers, with the method of metabolomics approach, will be measured at the time of baseline, 6 months and 12 months.
  • small molecule metabolites [ Time Frame: 12 months ]
    Biological markers, with the method of metabolomics approach, will be measured at the time of baseline, 6 months and 12 months.
  • Incidence rate of diabetes [ Time Frame: 6 months ]
    Evaluate the incidence of diabetes in prediabetes population who receive 12 months of either resistance training or aerobic exercise.
  • Incidence rate of diabetes [ Time Frame: 12 months ]
    Evaluate the incidence of diabetes in prediabetes population who receive 12 months of either resistance training or aerobic exercise.


Information By: Nanjing University of Traditional Chinese Medicine

Dates:
Date Received: September 24, 2015
Date Started: September 2015
Date Completion: September 2016
Last Updated: September 28, 2015
Last Verified: September 2015