Clinical Trial: Screening for Preeclampsia With Various Markers in Low-risk Pregnancy Populations

Study Status: Completed
Recruit Status: Completed
Study Type: Observational

Official Title: Screening Models for Early Detection of Late-onset Preeclampsia With Various Markers in Low-risk Pregnancy Populations

Brief Summary: For the prediction of late-onset preeclampsia (PE) in low risk women, the investigators established a cut-off value for sFlt-1/PlGF ratio and evaluated the combination models of Elecys, second trimester uterine artery (UtA) doppler, and fetoplacental proteins for Down syndrome screening.

Detailed Summary: A prospective study was carried on in Cha hospital. Serum samples for Down syndrome screening were assayed to estimate pregnancy-associated plasma protein-A (PAPP-A), alpha-fetoprotein , unconjugated estriol, human chorionic gonadotrophin , and inhibin-A. Women screened for Down syndrome were offered UtA Doppler at 20-24 weeks of gestation and then collected serial serum samples for sFlt-1/PlGF ratio at two time points (24-27 and 34-37 weeks' gestation).
Sponsor: CHA University

Current Primary Outcome: identification of patients at risk for late-onset preeclampsia with sFlt-1/PlGF ratio [ Time Frame: at delivery ]

Original Primary Outcome: Same as current

Current Secondary Outcome: identification of patients at risk for late-onset preeclampsia with combined biochemical markers [ Time Frame: at delivery ]

Original Secondary Outcome: Same as current

Information By: CHA University

Dates:
Date Received: July 19, 2012
Date Started: August 2009
Date Completion:
Last Updated: July 24, 2012
Last Verified: July 2012