Clinical Trial: Effect of Licorice and Hydrochlorothiazide on Plasma Potassium
Study Status: Completed
Recruit Status: Completed
Study Type: Interventional
Official Title: Effect of Licorice and Hydrochlorothiazide on Plasma Potassium
Brief Summary: This clinical trial is designed to study the effect of the combination of licorice and hydrochlorothiazide on plasma potassium levels in volunteers. In one arm, 10 healthy volunteers will be given 32 grams of licorice a day together with a 25 mg dose of daily hydrochlorothiazide for 14 days. This combination is compared with 32 grams of licorice a day for 14 days given in the other arm. The study is a randomized, open-label cross-over trial. There is at least a 3-week wash-out between the arms. The hypothesis is that the combination of licorice and hydrochlorothiazide will cause hypokalemia. The main outcome measure is the change in the plasma level of potassium between the arms.
Detailed Summary:
Sponsor: University of Oulu
Current Primary Outcome: Plasma Potassium [ Time Frame: Baseline and 2 weeks ]
Original Primary Outcome: Change in plasma potassium [ Time Frame: At the start of the arm, 1 week, 2 weeks ]
Current Secondary Outcome:
Original Secondary Outcome:
- Change in plasma renin activity [ Time Frame: At the start of the arm, 1 week, 2 weeks. ]
- Change in serum aldosterone [ Time Frame: At the start of the arm, 1 week, 2 weeks. ]
Information By: University of Oulu
Dates:
Date Received: January 17, 2008
Date Started: February 2008
Date Completion:
Last Updated: December 10, 2009
Last Verified: December 2009
