Clinical Trial: Assessment of Vascular Endothelial Function in Postural Tachycardia Syndrome

Study Status: Completed
Recruit Status: Completed
Study Type: Observational

Official Title: Assessment of Vascular Endothelial Function in Postural Tachycardia Syndrome (POTS)

Brief Summary:

The purpose of this study is to see if people with Postural Tachycardia Syndrome (POTS) have different levels of certain chemicals in their blood than people who don't have POTS. This study will test whether the blood vessels of people with POTS will react differently to certain tests than people without POTS.

The hypothesis of the study is:

Patients with POTS will have vascular endothelial dysfunction compared with control subjects.


Detailed Summary:
Sponsor: Vanderbilt University Medical Center

Current Primary Outcome: RH-PAT index [ Time Frame: The study will be complete in approximately 2 hours. There is no follow-up to this study. ]

The primary analysis of RH-PAT will involve a non-parametric, Mann Whitney U test of RH-PAT between POTS patients and Control subjects.


Original Primary Outcome: Same as current

Current Secondary Outcome:

Original Secondary Outcome: Comparison of continuous outcome measures between POTS patients and controls [ Time Frame: The study will be complete in approximately 2 hours. there is no follow-up to this study. ]

Secondary analysis will include non-parametric between group (POTS vs Controls) comparisons of continuous outcome measures. RH-PAT, CBF-RH, Framingham Risk Score, Homeostasis Model Assessment (HOMA) insulin resistance, Oxidative Stress, Inflammatory markers, and Other blood paramters.


Information By: Vanderbilt University Medical Center

Dates:
Date Received: February 18, 2011
Date Started: February 2011
Date Completion:
Last Updated: January 16, 2017
Last Verified: January 2017