Clinical Trial: Breathing Device in Postural Orthostatic Tachycardia Syndrome (POTS)
Study Status: Active, not recruiting
Recruit Status: Active, not recruiting
Study Type: Interventional
Official Title: Assessment of Inspiratory Breathing Devices to Improve Orthostatic Tolerance in Postural Orthostatic Tachycardia Syndrome
Brief Summary: The investigators will test whether breathing through an inspiratory resistance device will improve the ability to be upright and decrease heart rate increases on standing in patients with postural tachycardia syndrome.
Detailed Summary:
Chronic orthostatic intolerance, sometimes known as the postural tachycardia syndrome (POTS), is the most common disorder among patients seen at several centers specializing in diseases of the autonomic nervous system. It affects an estimated 500,000 people in the United States alone. POTS (excessive increase in heart rate [>30 min-1] on standing associated with orthostatic symptoms [including palpitation, chest pain syndrome, dyspnea on standing, mental clouding and difficulties with concentration], in the absence of orthostatic hypotension) can produce substantial disability among otherwise healthy people. Patients with POTS typically feel tired and run down. Many also report a myriad of symptoms that are hard to categorize, often involving fatigue. One study, from the Mayo Clinic, found that patients with POTS had a diminished quality of life when measured using a standard health status instrument (SF-36).
In this pilot study, we will test the hypothesis that breathing through an inspiratory resistance device will improve orthostatic tolerance and reduce orthostatic tachycardia in patients with postural tachycardia syndrome.
Sponsor: Alfredo Gamboa
Current Primary Outcome: Magnitude of orthostatic heart rate increase on upright posture [ Time Frame: 10 min ]
Original Primary Outcome: Same as current
Current Secondary Outcome:
- Symptoms rating with upright posture [ Time Frame: 10 min ]
- Hemodynamic changes on upright posture [ Time Frame: 10 min ]
Original Secondary Outcome: Same as current
Information By: Vanderbilt University Medical Center
Dates:
Date Received: August 18, 2009
Date Started: October 2009
Date Completion: December 2017
Last Updated: January 18, 2017
Last Verified: January 2017
