Clinical Trial: Palonosetron Versus Ramosetron for the Prevention of Postoperative Nausea and Vomiting

Study Status: Completed
Recruit Status: Completed
Study Type: Interventional

Official Title: A Randomized Double Blind Study to Evaluate Efficacy of Ramosetron and Palonosetron for Prevention of Postoperative Nausea and Vomiting After Gynaecological Laparoscopic S

Brief Summary: Ramosetron and palonosetron are more recently developed 5-hydroxytryptamine type 3 receptor antagonists and this randomized double blind study was designed to compare efficacy of ramosetron and palonosetron to prevent postoperative nausea and vomiting. Investigator hypothesized that palonosetron would have stronger and longer lasting antiemetic effect compared with ramosetron and evaluated the patients for the first 48 hours after surgery.

Detailed Summary:
Sponsor: Incheon St.Mary's Hospital

Current Primary Outcome: Incidence of postoperative nausea and vomiting for 48 hours after surgery [ Time Frame: for 48 hours after surgery ]

Original Primary Outcome: Same as current

Current Secondary Outcome: severity of nausea for 48 hours after surgery [ Time Frame: for 48 hours after surgery ]

Original Secondary Outcome: Same as current

Information By: Incheon St.Mary's Hospital

Dates:
Date Received: November 15, 2011
Date Started: May 2011
Date Completion:
Last Updated: November 17, 2011
Last Verified: November 2011