Clinical Trial: Aerobic Training for Management of Post-Concussion Syndrome in Adolescents

Study Status: Completed
Recruit Status: Completed
Study Type: Interventional

Official Title: Aerobic Training for Management of Post-Concussion Syndrome in Adolescents

Brief Summary: Sports-related concussions are common in adolescent-athletes. Prolonged recovery after concussion or post-concussion syndrome (PCS) is a public health problem. This project will determine the effectiveness of an aerobic exercise program for management of PCS and it will evaluate the influence of exercise on biologic correlates of PCS.

Detailed Summary: Concussion or mild traumatic brain injury (mTBI) is a public health problem and it is imperative that efficacious treatment protocols be developed to reduce the morbidity associated with PCS in adolescents. In adolescent athletes, timely return of normal neurocognitive function and return to sports safely is critical to normal development. The proposed study will fill a critical gap by systematically evaluating the potential efficacy of an aerobic training intervention for management of PCS in adolescents. To our knowledge, this will be the first randomized controlled study to evaluate the efficacy of aerobic training for treatment of PCS in adolescents as soon as four weeks after injury. The study will also improve our understanding of the pathophysiology of PCS and the biologic influence of aerobic training on PCS. The proposed study will fill a critical gap and inform the development of larger studies to assess the efficacy, and if proven efficacious, optimize the timing and intensity of aerobic training treatment protocols, thus transforming the care and limiting the adverse public impact of this condition.
Sponsor: Children's Hospital Medical Center, Cincinnati

Current Primary Outcome: Change from baseline in post-concussive symptoms at 10 week follow up [ Time Frame: 1 year ]

Original Primary Outcome: Same as current

Current Secondary Outcome: Change from baseline in cognitive functioning at 10 week follow up [ Time Frame: 1 year ]

Original Secondary Outcome: Same as current

Information By: Children's Hospital Medical Center, Cincinnati

Dates:
Date Received: September 5, 2013
Date Started: December 2013
Date Completion:
Last Updated: February 10, 2016
Last Verified: February 2016