Clinical Trial: Studies of Dermatologic Diseases Biospecimen Acquisition Protocol

Study Status: Recruiting
Recruit Status: Recruiting
Study Type: Observational

Official Title: Studies of Dermatologic Diseases-Biospecimen Acquisition Protocol

Brief Summary:

Background:

- Skin disease can have many causes. It can have widespread consequences, and in rare cases can lead to death. Researchers want to determine the causes of various types of skin diseases and find a way to treat them.

Objectives:

- To determine the causes of various skin diseases and find ways to treat them.

Eligibility:

  • People ages 2 and older who have:

    • A skin disease or at risk of developing a skin disease OR
    • A family member of persons with a skin disease
  • Healthy volunteers ages 2 and older

Design:

  • Participants will be screened under a separate protocol.
  • Participants may take a survey about how their skin condition affects their quality of life.
  • Participants will have a medical history and a physical exam including a detailed skin exam. Pictures will be taken of their skin to document any skin disease.

  • Participants will have specimens collected. This may include:

    • Several teaspoons of blood taken at each visit
    • Stool samples
    • Nail and body fluid (like saliva) samples
    • Background:

      • Skin diseases represent one of the most common medical problems in the-United States, affecting 1 in 3 people at any given time.
      • Complex interactions between genetic background and the environment are-relevant to understanding skin disease.
      • By studying dermatoses, we may gain insight into the complex host environment-interactions that give rise to or exacerbate these skin-conditions, and into links between inflammation and cancer.

      Objective:

      -To procure biologic samples for exploratory cellular, molecular, genetic and genomic biological studies from subjects with dermatologic conditions, subjects at risk for developing dermatologic conditions and healthy volunteers in the support of NIH biomedical studies

      Eligibility:

      -Subjects with or at risk for developing dermatologic diseases, family members of subjects with dermatologic diseases, or healthy volunteers, including adults and children.

      Design:

      • The purpose of this study is to examine, in an exploratory fashion, a variety of biologic assays relevant to the investigation of dermatologic diseases.
      • Approximately 50 subjects are anticipated to consent to the study each year with an accrual ceiling of 500 consented subjects planned over 10 years.

      Sponsor: National Cancer Institute (NCI)

      Current Primary Outcome: Procure biologic samples for exploratory cellular, molecular, genetic and genomic biological studies [ Time Frame: Time of collection ]

      Original Primary Outcome: Same as current

      Current Secondary Outcome:

      Original Secondary Outcome:

      Information By: National Institutes of Health Clinical Center (CC)

      Dates:
      Date Received: June 12, 2015
      Date Started: June 4, 2015
      Date Completion: January 31, 2027
      Last Updated: April 26, 2017
      Last Verified: April 20, 2017