Clinical Trial: Effect of Dosage of Metformin on Menstruation and Lipid Profile in Women With Polycystic Ovary Syndrome

Study Status: Completed
Recruit Status: Completed
Study Type: Interventional

Official Title: Effect of Dosage of Metformin on Menstruation and Lipid Profile in Women With Polycystic Ovary Syndrome

Brief Summary: Polycystic ovarian syndrome (PCOS) is the most common cause of anovulatory infertility and causes menstrual disruption in 6.6-6.8% of women in reproductive age and is characterized by insulin resistance, hyperinsulinemia, hyperandrogenism and anovulation. The gaol of this study was to assess the effects of metformin on menstrual disorders and lipid profile in women with PCOS in bandarabbas.

Detailed Summary:

Poly cystic ovarian syndrome (PCOS) is a common hormonal disorder in women that affecting of 6.6-6.8% of women o f reproductive age. PCOS associated with a broad range of clinical, hormonal and metabolic disorders consist of hirsutism, Obesity, Acne and elevated male hormones, anovulatory cycles, dyslipidemia and infertility.

Metformin is an oral hyperglycemic agent witch by decrease insulin resistance and improving serum glucose level in diabetic patients and anovulatory cyle in women with PCOS. The goal of this study is to evaluate the efficacy of different dosage of metformin on menstruation and lipid profile in women with PCOS in banda-abbas.


Sponsor: Hormozgan University of Medical Sciences

Current Primary Outcome: Lipid profile [ Time Frame: 6 month ]

The serum levels of Cholesterol, LDL, HDL and Triglyceride were measured before and after of treatment in both groups.


Original Primary Outcome: Same as current

Current Secondary Outcome: Hormone levels [ Time Frame: 6 month ]

LH, FSH, Testosterone


Original Secondary Outcome: Same as current

Information By: Hormozgan University of Medical Sciences

Dates:
Date Received: November 16, 2011
Date Started: February 2010
Date Completion:
Last Updated: November 18, 2011
Last Verified: November 2011