Clinical Trial: Polycystic Ovary Syndrome - Improving Outcomes

Study Status: Completed
Recruit Status: Completed
Study Type: Interventional

Official Title: Polycystic Ovary Syndrome - Targeting the Sympathetic Nervous System to Improve Outcomes

Brief Summary:

Polycystic ovary syndrome affects a striking 9-18% of Australian reproductive aged women and has been associated with a number of metabolic abnormalities.

Given the strong correlation between metabolic abnormalities and increased sympathetic activity, we hypothesise that reducing this activity using medication (moxonidine) can help improve the metabolic abnormalities, and therefore improve outcomes in polycystic ovary syndrome.


Detailed Summary:
Sponsor: Baker IDI Heart and Diabetes Institute

Current Primary Outcome: Microneurography [ Time Frame: 3 months ]

Microneurography is a technique developed to measure the sympathetic activitiy directly from the peroneal nerve. Microneurography will be performed at baseline visit and at 3 months follow up visit.


Original Primary Outcome: Same as current

Current Secondary Outcome:

  • Blood biochemistry measurement [ Time Frame: 3 months ]
    To assess the metabolic function of the participants we will be drawing fasting blood samples for biochemical analysis. These test will be performed at baseline and 3 months follow up visit
  • Oral glucose tolerance test [ Time Frame: 3 months ]
    A standard 75g glucose tolerance test will be performed. Venous blood will be taken before and 2 hours after the glucose drink was given.


Original Secondary Outcome: Metabolic measurement [ Time Frame: 3 months ]

To assess the metabolic function of the participants we will be drawing fasting blood samples for biochemical analysis of insulin, total cholesterol, triglycerides, HDL, LDL cholesterol, glucose, high sensitivity C reactive protein (hs-CRP) and leptin.

A standard 75g oral glucose tolerance test will also be performed.



Information By: Baker IDI Heart and Diabetes Institute

Dates:
Date Received: January 2, 2012
Date Started: May 2012
Date Completion:
Last Updated: January 11, 2016
Last Verified: January 2016