Clinical Trial: Ultrasonography in Juvenile Idiopathic Arthritis

Study Status: Completed
Recruit Status: Completed
Study Type: Observational

Official Title: Changes in Joint-Cartilage as a Measure of Outcome in Juvenile Idiopathic Arthritis - Assessed by Ultrasonography and Biomarkers

Brief Summary: The purpose of this study is to analyse the usability of ultrasonography together with biomarkers in the investigation of patients diagnosed with juvenile idiopathic arthritis. The investigators hypothesize that serum and urine markers of cartilage and bone synthesis and degradation, together with ultrasound measurements of joint cartilage thickness, are useful tools in the early evaluation of JIA patients, - as diagnostic, prognostic and monitoring methods.

Detailed Summary:
Sponsor: University of Aarhus

Current Primary Outcome: Joint cartilage thickness [ Time Frame: 1.5 years ]

Joint catilage thickness measured by ultrasonography: knee, ankle, wrist, metacarpophalangeal and proximal interphalangeal joints by MRI: one knee by plain radiographs: knee, ankel and wrist


Original Primary Outcome: Jointcartilage thickness [ Time Frame: 1.5 years ]

Jointcatilage thickness measured by ultrasonography: knee, ankle, wrist, metacarpophalangeal and proximal interphalangeal joints by MRI: one knee by plain radiographs: knee, ankel and wrist


Current Secondary Outcome: Level of different biomarkers in serum and urine [ Time Frame: 1.5 years ]

Level of bone- and cartilage-degradation biomarkers in serum and urine. COMP, CTX-II, RANKL/OPG, PYD/DPD


Original Secondary Outcome: Same as current

Information By: University of Aarhus

Dates:
Date Received: January 7, 2011
Date Started: October 2009
Date Completion:
Last Updated: March 21, 2012
Last Verified: March 2012