Clinical Trial: Targeting of Immune Response After Pneumococcal Vaccination

Study Status: Completed
Recruit Status: Completed
Study Type: Interventional

Official Title: Comparison of Immune Response in Pneumococcal Pneumonia and After Vaccination

Brief Summary: Pneumococcal polysaccharide vaccine does not confer protection against noninvasive pneumonia. The study aims to compare lymphocyte homing in pneumonia and in those receiving Pnc polysaccharide vaccine (PPV) or Pnc conjugate vaccine (PCV)

Detailed Summary: Pneumococcal polysaccharide vaccine does not confer protection against noninvasive pneumonia. The study compares the homing profiles of Pnc-specific plasmablasts in 15 patients with pneumonia and in 15 volunteers receiving Pnc polysaccharide vaccine (PPV) and 12 volunteers receiving Pnc conjugate vaccine (PCV)
Sponsor: Helsinki University Central Hospital

Current Primary Outcome: Expression of homing receptors on circulating plasmablasts in Pnc pneumonia and after vaccination [ Time Frame: Day 0 and Day 7-10 ]

HR on circulating Pnc-specific plasmablasts are determined in patients with pneumonia on day 7-10, in vaccinees on days 0 and 7


Original Primary Outcome: Same as current

Current Secondary Outcome:

Original Secondary Outcome:

Information By: Helsinki University Central Hospital

Dates:
Date Received: July 25, 2011
Date Started: January 2005
Date Completion:
Last Updated: July 25, 2011
Last Verified: January 2007