Clinical Trial: Change of Regional Ventilation During Spontaneous Breathing After Lung Surgery
Study Status: Recruiting
Recruit Status: Recruiting
Study Type: Observational
Official Title: Change of Regional Ventilation During Spontaneous Breathing After Lung Surgery
Brief Summary: Perioperative changes in regional ventilation by pulmonary electrical impedance tomography and spirometry will be investigated in patients at risk for postoperative pulmonary complications. Those patients undergo lung and flail chest surgery.
Detailed Summary: Postoperative pulmonary complications (Defined as pulmonary infection, pleural effusion, atelectasis, pneumothorax, bronchospasm, aspiration pneumonitis or respiratory insufficiency subsequent to surgery) increase the morbidity and mortality of surgical patients. Several independent factors determined by the patients' characteristics and the operative procedure increase the risk for those complications. The postoperative decrease of values measured by spirometry, such as the forced vital capacity (FVC) and forced expiratory volume in one second (FEV1), were found in patients after major surgical procedures for several days. The postoperative reduction of those measurement can be the result of general functional limitations in those patients (e.g. by postoperative pain) or the result of a regional postoperative pulmonary complication (e.g. atelectasis, pleural effusion). The method of the electrical impedance tomography (EIT) enables to visualize the regional ventilation within a transversal section of the lung in real time. Studies examining the change of pulmonary EIT for several days postoperatively in spontaneously breathing patients are lacking. The aim of the present study is to examine perioperative changes in regional ventilation in spontaneously breathing patients during their recovery after lung and flail chest surgery. Moreover, the association of those changes with expected changes in spirometry is tested. Finally, in patients with evident postoperative pulmonary complications the value of pulmonary EIT to detect those changes is investigated. The study should improve the knowledge about the development of postoperative pulmonary complications and test the scientific and clinical value of pulmonary EIT in those spontaneously breathing patients.
Sponsor: Wuerzburg University Hospital
Current Primary Outcome: Lateral Change from baseline in regional ventilation [ Time Frame: baseline and 3. postoperative day ]
Original Primary Outcome: Same as current
Current Secondary Outcome: Lateral Change from baseline in regional ventilation depending on side of surgery [ Time Frame: baseline and 3. postoperative day ]
Original Secondary Outcome: Same as current
Information By: Wuerzburg University Hospital
Dates:
Date Received: May 17, 2016
Date Started: May 2016
Date Completion: May 2017
Last Updated: May 23, 2016
Last Verified: May 2016