Clinical Trial: A Pharmacokinetic and Pharmacogenetic Study in Patients Receiving Sulfamethoxazole-trimethoprim Therapy
Study Status: Recruiting
Recruit Status: Recruiting
Study Type: Observational
Official Title: A Pharmacokinetic and Pharmacogenetic Study in Patients Receiving Sulfamethoxazole-trimethoprim Therapy
Brief Summary: In this study, we aim to investigate the incidence of the adverse reactions, the effectiveness and the gene polymorphism associated with the plasma level of sulfamethoxazole-trimethoprim and their metabolites (including N4-acetyl-sulfamethoxazole, sulfamethoxazole hydroxylamine and sulfamethoxazole-nitroso). And we also aim to investigate the factors associated with the sulfamethoxazole-trimethoprim induced acute psychosis.
Detailed Summary:
Sponsor: National Taiwan University Hospital
Current Primary Outcome: High performance liquid chromatography for drug plasma concentration [ Time Frame: Participants will be followed for the duration of the treatment course, an expected average of 21 days ]
Original Primary Outcome: Same as current
Current Secondary Outcome:
Original Secondary Outcome:
Information By: National Taiwan University Hospital
Dates:
Date Received: January 17, 2014
Date Started: January 2014
Date Completion: December 2017
Last Updated: July 31, 2014
Last Verified: July 2014