Clinical Trial: Impact of Large-Volume Pleural Effusions on Heart Function

Study Status: Recruiting
Recruit Status: Recruiting
Study Type: Observational

Official Title: The Assessment of Heart Function Using Transthoracic Echocardiogram (TTE) Following Thoracentesis on Large-volume Pleural Effusions

Brief Summary: The physiologic basis for relief from dyspnea after therapeutic thoracentesis remains poorly understood. Improvement of the heart and lung function may contribute to the dyspnea relief. But there is no data support this phenomenon. Transthoracic echocardiogram (TTE) is a non-invasive viewing of the heart, which can quickly assess the heart function through real-time images. The investigators performed thoracentesis on patients with large-volume pleural effusions, and utilized TTE to access the change of heart and lung function before and after this medical procedure.

Detailed Summary: Patients with large pleural effusions often experience dramatic and immediate relief from dyspnea after therapeutic thoracentesis. Although this is a well-recognized phenomenon, the physiologic basis for such relief remains poorly understood. Primary physiologic basis for the relief in dyspnea after thoracentesis may include the improvement of the heart and lung function. In some cases the improvement in breathlessness cannot be attributed to the improvement of gas exchange, due to the atelectatic lung(not fully expansion of the lung). Transthoracic echocardiogram (TTE) is a non-invasive, real-time viewing of the internal parts of the heart using ultrasound, which can get highly accurate and quick assessment of the various heart images, though which doctors can quickly assess a patient's heart valves and degree of heart muscle contraction.
Sponsor: Beijing Chao Yang Hospital

Current Primary Outcome: changes of the TTE diameter after large-volume thoracentesis [ Time Frame: baseline, immediately after drainage, 24 h after the thoracentesis ]

change of the UCG diameter of the patients, including : Left ventricular: Left ventricular end-diastolic diameter(LVEDD）, Left ventricular end-systolic diameter（LVESD）, Left ventricular end-diastolic volume （LVEDV ）, Left ventricular end-systolic volume（ LVESV）, Left ventricular ejection fraction（LVEF）,Stroke volume（SV）,Cardiac output（CO），left ventricular diastolic function, including：E、A、E/A、E/Em、Em、Am（By PW&DTI）；Global longitudinal strain(GLS）; right ventricular：Basal and mid-cavity transversal right ventricular diameter, right ventricular free wall thickness, Tricuspid annular plane systolic excursion（TAPSE）, Fractional area change（FAC）, right ventricular systolic strain, Left and right atrial volume, coronary artery diameter


Original Primary Outcome: Same as current

Current Secondary Outcome: changes of the distances on 6-MWT after large-volume thoracentesis [ Time Frame: baseline, immediately after drainage, 24 h after the thoracentesis ]

6-MWT is the distances on the 6-minute walk test


Original Secondary Outcome: Same as current

Information By: Beijing Chao Yang Hospital

Dates:
Date Received: September 6, 2015
Date Started: September 2015
Date Completion: December 2016
Last Updated: September 11, 2015
Last Verified: September 2015