Clinical Trial: Outcome of Patients Undiagnosed Under Medical Thoracoscopy

Study Status: Completed
Recruit Status: Completed
Study Type: Observational

Official Title: Outcome of Patients Who Could Not Have Been Diagnosed by Medical Thoracoscopy

Brief Summary:

Medical thoracoscopy (MT) under local anaesthetic and mild sedation, an established method in the diagnosis of pleural diseases. MT has an overall diagnostic yield above 90% for malignant pleural diseases and pleural tuberculosis. However, others who are diagnosed as fibrinous pleuritis make confusion in clinicians. Whether these patients are firmly followed or not ? The investigators do not know the answer of this question.

In this study the investigators aimed to investigate the outcome of the patients who are diagnosed as fibrinous pleuritis on MT biopsies.


Detailed Summary: Medical thoracoscopy (MT) under local anaesthetic and mild sedation, an established method in the diagnosis of pleural diseases with a sensitivity above 90% and specificity of 1000% for malignant pleural diseases and pleural tuberculosis. Except these two groups of patients, in others pleural histopathological diagnosis is defined as "non-specific pleuritis" or "fibrinous pleuritis". Authors say that the natural evolution of these patients is poorly understood. Some of these patients was later established false negative cases for malignant pleural diseases. Clinical guidelines recommend close observation of patients with undiagnosed exudative effusions, although the length and follow-up regime is not defined, yet. In this study the investigators examine the outcome of patients who are diagnosed as fibrinous pleuritis by MT.
Sponsor: Eskisehir Osmangazi University

Current Primary Outcome: Accuracy of medical thoracoscopy for patients diagnosed as fibrinous pleuritis. [ Time Frame: 2 years ]

During 2 years after medical thoracoscopy, the diagnostic sensitivity, specificity, positive predictive value and negative predictive value are determined in the patients diagnosed as fibrinous pleuritis.


Original Primary Outcome: Same as current

Current Secondary Outcome: To determine the factors which point the false positive diagnosis of fibrinous pleuritis. [ Time Frame: 2 years ]

The factors predictive of false-negative biopsy results in the patients with a diagnosis of fibrinous pleuritis are determined by using logistic regression analysis .


Original Secondary Outcome: Same as current

Information By: Eskisehir Osmangazi University

Dates:
Date Received: May 16, 2011
Date Started: February 2002
Date Completion:
Last Updated: September 24, 2012
Last Verified: September 2012