Clinical Trial: Comparison of Clopidogrel Versus Ticagrelor Therapy for Atherosclerotic Plaque Inflammation

Study Status: Completed
Recruit Status: Completed
Study Type: Interventional

Official Title: Comparison of Clopidogrel Versus Ticagrelor Therapy for Atherosclerotic Plaque Inflammation: Serial FDG PET/CT Imaging Study of Carotid Artery and Ascending Aorta

Brief Summary:

Objectives: To compare the effects of clopidogrel versus ticagrelor on atherosclerotic plaque inflammation using serial FDG PET/CT imaging of carotid artery and ascending aorta.

Hypothesis: Thrombosis and inflammation are tightly linked rather than separate entities. Therefore, P2Y12 receptor inhibitors may have an anti-ischemic effect by inhibiting plaque inflammation, and ticagrelor may be superior in efficacy to clopidogrel.


Detailed Summary:
Sponsor: CHEOL WHAN LEE, M.D., Ph.D

Current Primary Outcome: change (follow-up minus baseline) in standardized FDG uptake value within the regions of interest [ Time Frame: 6months ]

Analyses of FDG activity will be quantified on common carotid arteries and ascending aorta of the aortic arch. Primary endpoint is change (follow-up minus baseline) in standardized FDG uptake value within the regions of interest, known as a target-to-background ratio(blood-normalized standardized uptake value).


Original Primary Outcome: change (follow-up minus baseline) in standardized FDG uptake value within the regions of interest [ Time Frame: 6months ]

Analyses of FDG activity will be quantified on common carotid arteries and ascending aorta of the aortic arch (see figure below). Primary endpoint is change (follow-up minus baseline) in standardized FDG uptake value within the regions of interest, known as a target-to-background ratio(blood-normalized standardized uptake value).


Current Secondary Outcome:

  • Serial changes of high-sensitivity C-reactive protein [ Time Frame: 6months ]
  • Serial changes of lipid battery [ Time Frame: 6months ]
    lipid battery (total cholesterol, triglyceride, HDL-cholesterol, LDL-cholesterol).


Original Secondary Outcome: Serial changes of high-sensitivity C-reactive protein, lipid battery [ Time Frame: 6months ]

Serial changes of high-sensitivity C-reactive protein, lipid battery (total cholesterol, triglyceride, HDL-cholesterol, LDL-cholesterol).


Information By: Asan Medical Center

Dates:
Date Received: July 19, 2013
Date Started: September 2013
Date Completion:
Last Updated: February 25, 2016
Last Verified: February 2016