Clinical Trial: Management of Third-stage of Labor After Second Trimester Medical Pregnancy Termination

Study Status: Recruiting
Recruit Status: Recruiting
Study Type: Interventional

Official Title: Effect of Intra-venous Oxytocin Injection After Fetal Expulsion in Management of Third-stage of Labor After Second Trimester Medical Pregnancy Termination

Brief Summary: Prospective randomized trail which compare 2 regimens for third-stage management after second trimester medical pregnancy termination : 10UI intra venous oxytocin or no additional medication after fetal expulsion. Primary outcome was the incidence of placental retention.

Detailed Summary: Complication of third stage of labor in second trimester medical pregnancy termination is not well studied. Accord to publications, the placental retention rate is 30 to 40% in these situations. Placental retention may be associated with increased blood loss, increased requirement for blood transfusion anesthetic and operative complications, and infectious morbidity. The high incidence of retained placenta is an area of clinical concern. Publications reveal a wide variation in practices but there are only few studies about third stage of labor in second trimester medical pregnancy termination. The study is a prospective randomized trial. Two third stage management strategies are compared: 10 units of intra venous oxytocin (group 1) and no additional medication (group 2) after fetal expulsion. It concerns pregnancies between 14 and 28 weeks gestation.
Sponsor: University Hospital, Bordeaux

Current Primary Outcome: Incidence of placental retention [ Time Frame: Up to 30 minutes after fetal expulsion ]

Original Primary Outcome: Same as current

Current Secondary Outcome:

  • Incidence of partial placental retention [ Time Frame: Up to 1 hour after fetal expulsion ]
  • Incidence of digital exploration [ Time Frame: Up to 1 hour after fetal expulsion ]
  • Incidence of blunt curettage [ Time Frame: Up to 1 hour after fetal expulsion ]
  • Incidence of post-partum hemorrhage [ Time Frame: Up to 1 hour after fetal expulsion ]
  • Blood loss [ Time Frame: Up to 1 hour after fetal expulsion ]


Original Secondary Outcome: Same as current

Information By: University Hospital, Bordeaux

Dates:
Date Received: November 17, 2016
Date Started: September 2016
Date Completion: September 2017
Last Updated: November 18, 2016
Last Verified: November 2016