Clinical Trial: A Pilot Study to Evaluate Optical Spectroscopy of Pigmented Skin Lesions

Study Status: Completed
Recruit Status: Completed
Study Type: Observational

Official Title: A Pilot Study to Evaluate the Correlation Between Modified Two Layer Diffuse Optical Spectroscopy With the Clinical and Histological Examinations of Pigmented Skin Lesions

Brief Summary: The incidence of malignant melanoma has increased dramatically in recent decades. In 1930, the lifetime risk of an individual in the United States developing melanoma was 1 in 1,500. This has been exponentially increasing over the years with the risk estimated to be 1 in 75 in 2000 . According to the American Cancer Society, approximately 59,580 new cases of melanoma will be diagnosed in the United States in 2005 and about 7,770 people are expected to die of the disease.

Detailed Summary:

The researcher ucan use special imaging devices to obtain information about a typical mole and melanoma and use this information to determine the different between malignant and benign melanized lesions. The imaging devices are, Modified Two Layer Diffuse Optical Spectroscopy,multi-spectral imaging, and Spatially Modulated Quantitative Spectroscopy can use to measure atypical moles and melanoma and correlate the results of the biopsy tissue histology.

The imaging devices can quantify melanin, oxy and deoxy hemoglobin concentration, water, lipid and reduced scattering coefficients and can compare results to histopathologic. Atypical moles and melanoma have a different optical profile based on physiological parameters compared to benign nevus.


Sponsor: University of California, Irvine

Current Primary Outcome: Measure atypical moles and melanoma [ Time Frame: 4 weeks ]

Optical Spectroscopy imaging of atypical moles and melanoma to correlate results from the results of the biopsy tissue histology


Original Primary Outcome: establish the variance of optical measurements in human pigmented lesions (benign and malignant). [ Time Frame: 2 years ]

Current Secondary Outcome:

Original Secondary Outcome:

Information By: University of California, Irvine

Dates:
Date Received: March 4, 2008
Date Started: July 2008
Date Completion:
Last Updated: February 8, 2017
Last Verified: February 2017