Clinical Trial: Peripheral Venous Catheter Trial: 3 Day Versus No Routine Change

Study Status: Completed
Recruit Status: Unknown status
Study Type: Interventional

Official Title: Peripheral Venous Catheter Trial: 3 Day Versus No Routine Change

Brief Summary: The purpose of this study is to investigate the effects of extending the dwell time of peripheral intravenous cannulas on clinical outcomes and cost.

Detailed Summary:

Among hospitalized patients, intravenous therapy is the most common invasive procedure. It is associated with a phlebitis rate of between 1.1% and 63% and a central venous catheter related bacteremia rate of approximately 3.0%. Catheter related blood-stream infections have an attributable mortality rate of 12% to 25%. Factors thought to be associated with these complications include insertion techniques, catheter securement, type of catheter used, type of infusate and additives, post-insertion catheter care and length of time the catheter remains in place.

Current Centers of Disease Control Guidelines provide direction for intravenous therapy management including a recommendation that peripheral intravenous catheters should be re-sited every 72-96 hours. Data underpinning the recommendation was collected in 1992, over a decade ago. Since that time, there have been improvements in catheter design and composition, and prospective surveillance studies have demonstrated the safety of longer dwell times. To date, these observations have not been validated in adults, using randomized controlled trial methodology.

Re-siting intravenous cannulas causes discomfort to patients and has a high recurrent cost. The primary aim of the present study is to compare the rates of peripheral catheter-related blood stream infection, catheter-related local infection, phlebitis and obstruction between two groups of patients - those having routine catheter changes every 72 hours and those having catheter changes only when clinically indicated.

Specific hypotheses:

That changing intravenous peripheral catheters when indicated by clinical signs compared to changing intravenous catheters every 3 days reduces the incidence of intravenous catheter relate
Sponsor: Royal Brisbane and Women's Hospital

Current Primary Outcome: Phlebitis during the course of the infusion and up to 48 hours after peripheral venous catheter removal

Original Primary Outcome: Same as current

Current Secondary Outcome:

  • Infiltration permeation of IV fluid into the interstitial compartment
  • Local infection at the site of the catheter
  • Catheter-related blood stream infection
  • Catheter colonization
  • Cost


Original Secondary Outcome: Same as current

Information By: Royal Brisbane and Women's Hospital

Dates:
Date Received: February 11, 2005
Date Started: March 2004
Date Completion: December 2004
Last Updated: June 23, 2005
Last Verified: February 2005