Clinical Trial: Pakistan Epidemiological Survey in Acute Pharyngitis
Study Status: Completed
Recruit Status: Completed
Study Type: Observational
Official Title: Pakistan Epidemiological Survey in Acute Pharyngitis
Brief Summary:
GABHS are common etiological agents for acute pharyngitis. However, local data is limited and large scale surveillance studies have not been done. This study aims to evaluate the disease burden in the community due to GABHS.
In this study, patients presenting with signs of acute pharyngitis will be evaluated. Patients with fulfilling the inclusion criteria will be tested for Rapid Antigen Detection test (RADT)
Detailed Summary:
Pharyngitis is a common reason for patients' visit to doctors. Group A beta- hemolytic streptococci (GABHS) account for 15-30 percent of cases of acute pharyngitis in children and 5 to 20 percent in adults1.
Because the signs and symptoms of GABHS pharyngitis overlap extensively with other infectious causes, making a diagnosis based solely on clinical findings is difficult. In patients with acute febrile respiratory illness, physicians accurately differentiate bacterial from viral infections using only the history and physical findings about one half of the time.2 No single element of the patient's history or physical examination reliably confirms or excludes GABHS pharyngitis.3 Sore throat, fever with sudden onset (temperature greater than 100.4° F [38° C]), and exposure to Streptococcus within the preceding two weeks suggest GABHS infection. Cervical node lymphadenopathy and pharyngeal or tonsillar inflammation or exudates are common signs. Palatal petechiae and scarlatiniform rash are highly specific but uncommon; a swollen uvula is sometimes noted. Cough, coryza, conjunctivitis, and diarrhea are more common with viral pharyngitis.
The original Centor score uses four signs and symptoms to estimate the probability of acute streptococcal pharyngitis in adults with a sore throat.4 The score was later modified by adding age and validated in 600 adults and children.5,6 The cumulative score determines the likelihood of streptococcal pharyngitis.
Rapid Antigen Detection Tests (RADTs) have been developed for the identification of GABHS directly from throat swabs. Although these rapid tests are more expensive than blood agar culture, they provide results faster. Rapid identification and treatment of patients with streptococcal pharyngitis can reduce the risk of the spre
Sponsor: Suresh Kumar
Current Primary Outcome: To evaluate the prevalence of GABHS in patients with acute pharyngitis. [ Time Frame: 12 months ]
Original Primary Outcome: Same as current
Current Secondary Outcome:
- To study the prevalence of GABHS in acute pharyngitis across different age groups. [ Time Frame: 12 months ]
- To study the correlation of centor score and RADT results. [ Time Frame: 12 months ]
Original Secondary Outcome: Same as current
Information By: Hill Park General Hospital
Dates:
Date Received: November 1, 2012
Date Started: November 2012
Date Completion:
Last Updated: September 12, 2014
Last Verified: September 2014
