Clinical Trial: Studying Biomarkers in Samples From Younger Patients With Wilms Tumor
Study Status: Completed
Recruit Status: Completed
Study Type: Observational
Official Title: Validation of Copy Number Changes by MLPA as Predictors of Relapse in Wilms Tumor
Brief Summary:
RATIONALE: Studying samples of tissue and urine from patients with cancer in the laboratory may help doctor learn more about changes that occur in DNA and identify biomarkers related to cancer.
PURPOSE: This research trial studies biomarkers in samples from younger patients with Wilms tumor.
Detailed Summary:
OBJECTIVES:
- To determine a unique molecular "finger print" of primary Wilms tumor arising in ethnically diverse children who are at increased risk to develop this lethal malignancy and subsequently relapse.
- To determine a unique protein "finger print" from the urine of ethnically diverse children who develop Wilms tumor and subsequent relapse.
OUTLINE: Formalin-fixed paraffin-embedded and snap-frozen primary tissue samples, and urine samples collected at the time of diagnosis and before treatment, are analyzed for molecular and protein profile by MALDI-TOF mass spectroscopy, western blotting, immunohistochemistry, and reverse-transcriptase polymerase chain reaction (RT-PCR) assays.
Sponsor: Children's Oncology Group
Current Primary Outcome:
- Molecular "finger print" of primary Wilms tumor in ethnically diverse children
- Protein "finger print" from the urine of ethnically diverse children
Original Primary Outcome: Same as current
Current Secondary Outcome:
Original Secondary Outcome:
Information By: Children's Oncology Group
Dates:
Date Received: April 11, 2012
Date Started: April 2012
Date Completion:
Last Updated: May 17, 2016
Last Verified: May 2016
