Clinical Trial: Photodynamic Therapy During Supportive Periodontal Therapy
Study Status: Completed
Recruit Status: Completed
Study Type: Interventional
Official Title: Effects of Photodynamic Therapy on Clinical and Immunological Parameters in a Group of Periodontal Patients Undergoing Supportive Periodontal Therapy
Brief Summary: 27 subjects on SPT, each with at least two residual pockets ≥5mm, were recruited for this randomised, split-mouth controlled trial, providing a total of 72 sites. At baseline, probing pocket depth (PPD), recession, clinical attachment level (CAL), plaque and bleeding on probing (BOP) of all sites were examined. Gingival crevicular fluid (GCF) were collected to determine level of cytokines IL-1β, -6, -8, TNF-α and MMP-8 via ELISA. Control sites received subgingival instrumentation and rubber cup polishing with pumice. In addition test sites received a single application of PDT using Fotosan® and photosensitizer consisting of toludine blue O solution. The subjects were recalled three and six months later and re-examined. Site level analysis was performed.
Detailed Summary:
Sponsor: National University, Singapore
Current Primary Outcome: Difference in percentage change in probing pocket depth [ Time Frame: 6 months ]
Original Primary Outcome: Same as current
Current Secondary Outcome:
- Bleeding on probing [ Time Frame: 6 months ]
- Clinical attachment level [ Time Frame: 6 months ]
- Recession [ Time Frame: 6 months ]
- Cytokines level [ Time Frame: 6 months ]
Original Secondary Outcome: Same as current
Information By: National University, Singapore
Dates:
Date Received: January 25, 2016
Date Started: June 2013
Date Completion:
Last Updated: January 27, 2016
Last Verified: January 2016
