Clinical Trial: Predictive Score for Neonatal Mortality for Women With Premature Rupture of Membranes Between 22 and 28 Weeks of Gestation
Study Status: Recruiting
Recruit Status: Recruiting
Study Type: Observational
Official Title: Predictive Score for Neonatal Mortality for Women With Premature Rupture of Membranes Between 22 and 28 Weeks of Gestation
Brief Summary:
Pretern premature rupture of the membranes (PPROM) remains the leading cause of preterm deliveries and neonatal mortality and morbidity. PPROM is defined as rupture of the fetal membranes prior to 37 weeks' gestation. PPROM complicates 2-4% of all pregnancies and accounts for approximately 30 % of preterm births.
The etiology of PPROM remains elusive. PPROM is one of the main causes of prematurity and its complications, such as newborn respiratory distress syndrome, neonatal sepsis, necrotizing enterocolitis, intraventricular hemorrhage, perventricular leucomalacia, varying degrees of lung hypoplasia and bronchopulmonary dysplasia. All these factors contribute greatly to an increase in neonatal morbidity and mortality Management of PPROM followed actual guidelines. Conservative management to prolong a pregnancy is a classical approach to treat PPROM before 34 weeks' gestation in association with antibiotic therapy and corticosteroids.
Maternal and neonatal data were collected from maternal and newborns medical records.
Detailed Summary:
Sponsor: Centre Hospitalier Universitaire, Amiens
Current Primary Outcome: The purpose was to determine which antepartum criteria were efficient to predict neonatal death, in order to create a predictive prognostic antenatal index of mortality. [ Time Frame: 1 day ]
Original Primary Outcome: Survival rate of newborns following hospitalization in patients with premature rupture of membranes between 22 + 0 and 31 + 6 SA inclusive [ Time Frame: 1 day ]
Current Secondary Outcome:
Original Secondary Outcome:
Information By: Centre Hospitalier Universitaire, Amiens
Dates:
Date Received: March 31, 2017
Date Started: January 1, 2017
Date Completion: January 6, 2020
Last Updated: May 11, 2017
Last Verified: May 2017
