Clinical Trial: Third Molar Clinical Trials: Pericoronitis Studies
Study Status: Completed
Recruit Status: Completed
Study Type: Observational
Official Title: Pericoronitis; Oral and Systemic Inflammation
Brief Summary: The purpose of this research study is to find out if the infection around 3rd molars and the resulting inflammation around the gum also produces a general systemic inflammation.
Detailed Summary: Relate signs and symptoms of mild pericoronitis, an oral clinical condition characterized by intense inflammation and pain around a lower 3rd molar, to indicators of oral and systemic inflammation in patients seeking treatment for the condition.
Sponsor: University of North Carolina, Chapel Hill
Current Primary Outcome: Quality of Life [ Time Frame: one year ]
Original Primary Outcome: Same as current
Current Secondary Outcome: inflammatory mediators [ Time Frame: one year ]
For enrolled patients with minor signs and symptoms of pericoronitis:
Assess oral inflammation
- Levels of "orange/red complex" anaerobic bacteria in biofilm samples from distal of all 2nd molars and distal of affected 3rd molar.
- Levels of GCF inflammatory mediators, PGE2 and IL-1ß from distal of all 2nd molars and mesial of 1st molars. If the first molar is absent, the mesial of the next most anterior tooth in the quadrant.
- Assess the possible association between oral inflammation and systemic inflammation -Serum C-Reactive Protein and IL-6 levels at the time of active symptoms
Original Secondary Outcome: Same as current
Information By: University of North Carolina, Chapel Hill
Dates:
Date Received: June 17, 2013
Date Started: January 2008
Date Completion:
Last Updated: February 6, 2014
Last Verified: February 2014