Clinical Trial: Surgical and Non-surgical Treatment of Peri-implantitis

Study Status: Recruiting
Recruit Status: Recruiting
Study Type: Interventional

Official Title: Surgical and Non-surgical Treatment of Peri-implantitis: Randomised Controlled Trial of 12-months Follow-up

Brief Summary: This study will compare surgical and non surgical treatments of peri-implantitis. Peri-implantitis is an inflammation around dental implants that can lead to the loss of the implant over time if no treatment is established. The signs of peri-implantitis included bleeding of the gingiva, swelling and redness. Most of times there is no pain. Patients presenting with these characteristics will be included at random to one of the treatment groups. Those allocated to the non-surgical group will received implant cleansing after local anesthesia using adequate instruments. In the surgical group, patients will be submitted to a surgical procedure around the implant for visualization and cleansing also after local anesthesia. All patients will be followed over a 12-month period. The hypothesis is that surgical treatment is better than non-surgical treatment regarding clinical, radiographic, microbiological, and immunological.characteristics.

Detailed Summary:
Sponsor: Federal University of Rio Grande do Sul

Current Primary Outcome: Pocket depth reduction [ Time Frame: 12 months ]

Original Primary Outcome: Same as current

Current Secondary Outcome:

  • Clinical attachment level changes [ Time Frame: 12 months ]
  • Alveolar bone level changes [ Time Frame: 12 months ]
  • Subgingival microbiota changes [ Time Frame: 12 months ]
  • Gingival crevicular fluid immune-inflammatory biomarkers [ Time Frame: 12 motnhs ]
  • Serum biomarkers of inflammation [ Time Frame: 12 months ]
  • Bleeding on probing [ Time Frame: 12 months ]


Original Secondary Outcome: Same as current

Information By: Federal University of Rio Grande do Sul

Dates:
Date Received: September 12, 2014
Date Started: June 2014
Date Completion: October 2018
Last Updated: September 15, 2014
Last Verified: September 2014