Clinical Trial: Effects of 2 Different Doses of Pantoprazole on Gastric pH and Recurrent Bleeding in Patients Who Bled From Peptic Ulcers

Study Status: Completed
Recruit Status: Completed
Study Type: Interventional

Official Title:

Brief Summary:

Endoscopic treatment of bleeding peptic ulcers is effective to prevent rebleeding. Adjuvant medical treatment to increase gastric pH may further decrease rebleeding. Recent studies on potent acid suppression by proton pump inhibitors (PPI) demonstrated the efficacy in preventing rebleeding. Lau demonstrated that high dose intravenous infusion of omeprazole decreased rebleeding in peptic ulcers with stigmata of recent hemorrhage.

There is little data regarding the effect of pantoprazole on bleeding peptic ulcers. Furthermore, the optimal dose of PPI is unknown. Few studies have included measurement of gastric pH in addition to clinical outcome.

This study compares the effect of two doses of intravenous pantoprazole with no acid suppression in bleeding peptic ulcers after endoscopic therapy. In addition to the usual clinical endpoints, gastric pH is monitored to study the relation of pH elevation and the clinical outcome.


Detailed Summary:
Sponsor: Kwong Wah Hospital

Current Primary Outcome: Rebleeding rate within 30 days after endoscopic therapy

Original Primary Outcome: Same as current

Current Secondary Outcome:

  • Transfusion requirement
  • duration of hospital stay
  • need for operative intervention
  • mortality rate
  • gastric pH
  • side effects of pantoprazole


Original Secondary Outcome: Same as current

Information By: Kwong Wah Hospital

Dates:
Date Received: January 17, 2006
Date Started: January 2002
Date Completion:
Last Updated: January 17, 2006
Last Verified: January 2006