Clinical Trial: Comparison of Low Against High Regimen of Proton Pump Inhibitors for Treatment of Acute Peptic Ulcer Bleeding
Study Status: Not yet recruiting
Recruit Status: Not yet recruiting
Study Type: Interventional
Official Title: Low Dose Against High Dose of Proton Pump Inhibitors in Treatment Acute Peptic Ulcer Bleeding
Brief Summary: Evaluate the efficacy of Two different regimens of proton pump inhibitors High against Low in the management of acute peptic ulcer bleeding
Detailed Summary: Evaluate the efficacy of Two different regimens of proton pump inhibitors in the management of acute peptic ulcer bleeding First: loading dose 80 mg then 8mg/h iv continuous infusion for 3 days Second Loading dose 80 mg the 40 mg every 12 h for 3 days
Sponsor: Damascus Hospital
Current Primary Outcome: Mortality [ Time Frame: 1 month ]
Original Primary Outcome: Same as current
Current Secondary Outcome:
- Rebleeding [ Time Frame: one month ]recurrent melena (black, tarry stool) or recurrent Hematemesis or coffee-ground emesis or recurrent hematochezia after begin treatment
- Surgery [ Time Frame: one month ]need for surgery
- Length of hospital stay [ Time Frame: one month ]
- Blood transfusions [ Time Frame: one month ]number of transfusion blood unites during admission
Original Secondary Outcome: Same as current
Information By: Damascus Hospital
Dates:
Date Received: March 14, 2016
Date Started: December 2020
Date Completion: July 2021
Last Updated: December 26, 2016
Last Verified: December 2016
