Clinical Trial: Alterations in Connective Tissue in Patients With or Without Pelvic Organ Prolapse

Study Status: Completed
Recruit Status: Completed
Study Type: Observational

Official Title: Alterations in Connective Tissue in Patients With or Without Pelvic Organ Prolapse.

Brief Summary: The aim of our study is to investigate the alterations in connective tissue of vaginal wall in patients with and without pelvic organ prolapse (POP).

Detailed Summary:

The tissue samples were taken from the anterior wall of vagina in the midline close to cervix or apex. The tissue samples were collected from the vaginal wall of the patients with pelvic organ prolapse (n=39) during vaginal prolapse surgery. Control samples (n=39) were taken from patients after vaginal or laparoscopic removal of the uterus.

The formalin-fixed and paraffin embedded tissue samples were stained with Verhoeff van Gieson and Movat's pentachrome. Samples were examined by pathologist and gynecologist blinded as to the other investigator and to the pelvic organ prolapse status. In case of discrepancy investigators evaluated the samples together to gain consensus.

Sponsor: Turku University Hospital

Current Primary Outcome: The elastin content in tissue samples in patients with or without pelvic organ prolapse. [ Time Frame: september 2012 ]

Original Primary Outcome: The elastin content in tissue samples in patients with or without POP. [ Time Frame: september 2012 ]

Current Secondary Outcome: The collagen content in tissue samples in women with or without pelvic organ prolapse. [ Time Frame: September 2012 ]

Original Secondary Outcome: The collagen content in tissue samples in women with or without POP. [ Time Frame: September 2012 ]

Information By: Turku University Hospital

Dates:
Date Received: December 12, 2012
Date Started: November 2009
Date Completion:
Last Updated: May 8, 2014
Last Verified: May 2014