Clinical Trial: Cognitive Dysfunction in MS: Using Altered Brain Oscillation to Link Molecular Mechanisms With Clinical Outcomes

Study Status: Not yet recruiting
Recruit Status: Not yet recruiting
Study Type: Observational

Official Title: Cognitive Dysfunction in MS: Using Altered Brain Oscillation to Link Molecular Mechanisms With Clinical Outcomes

Brief Summary: Up to 65% of patients with multiple sclerosis (MS) experience cognitive dysfunction. Diminution of mental capacity has a pervasive and profound impact on their quality of life. Subtle changes in white matter predict cognitive changes in these patients but how this disrupts brain function remains unclear. Development of effective therapeutics to restore normal cognition hinges on elucidating these functional changes. The investigators seek to uncover the patho-physiological basis for cognitive decline in MS. The investigators hypothesize that cognitive decline originates from disrupted gamma oscillations and that gamma oscillations are disrupted by molecular changes triggered by demyelination.

Detailed Summary:
Sponsor: The Hospital for Sick Children

Current Primary Outcome:

  • Neuronal responses during simple and choice reaction time tasks [ Time Frame: 60 minutes ]
    Video-based eye tracking in the MEG
  • MRI scans of the brain, including Diffusion Tensor Imagine (DTI) [ Time Frame: 90 minutes ]
  • Neurocognitive Testing [ Time Frame: 90 minutes ]
    Penn Computerized Neurocognitive Battery
  • Neurological Exam - Standard physical exam performed by the neurologist to determine the Expanded Disability Status Scale (EDSS) score. [ Time Frame: 20 minutes ]
  • Clinical Interview [ Time Frame: 10 minutes ]
    Series of questions about the participant's demographic and clinical information including, current and past health, family history, and medications.


Original Primary Outcome: Same as current

Current Secondary Outcome:

Original Secondary Outcome:

Information By: The Hospital for Sick Children

Dates:
Date Received: January 3, 2017
Date Started: June 2017
Date Completion: June 2018
Last Updated: February 23, 2017
Last Verified: February 2017