Clinical Trial: The Use of Human Acellular Dermal Matrix to Improve Infraauricular Depressed Deformities and Frey's Syndrome

Study Status: Completed
Recruit Status: Completed
Study Type: Interventional

Official Title: The Use of Human Acellular Dermal Matrix in the Prevention of Infraauricular Depressed Deformities and Frey's Syndrome Following Total Parotidectomy

Brief Summary: The aim of the study was to explore whether human acellular dermal matrix (ADM) implantation could prevent infraauricular depressed deformities and Frey's syndrome following total parotidectomy.

Detailed Summary:

Seventy patients who underwent total parotidectomy were selected for inclusion in the study. We analyzed 41 cases of total parotidectomy (control group) and 29 cases of simultaneous ADM implantation following total parotidectomy (ADM group) for infraauricular depressed deformities and the presence of gustatory flushing or sweating. The follow-up periods ranged from 6 months to 7 years.

The Results showed facial contours and bilateral symmetry improved after surgery in the ADM group. In the control group, an infraauricular depressed deformity was evident in all 41 cases. Frey's syndrome was recorded in one patient (3.4%) from the ADM group and 14 patients (34.1%) from the control group. No cases of immune rejection, infection, hematoma, or salivary fistula were observed in either group.


Sponsor: West China Hospital

Current Primary Outcome: infraauricular depressed deformities and the presence of gustatory flushing or sweating [ Time Frame: from 6 months to 7 years after surgery ]

to explore whether human acellular dermal matrix (ADM) implantation could prevent infraauricular depressed deformities and Frey's syndrome following total parotidectomy


Original Primary Outcome: Same as current

Current Secondary Outcome:

Original Secondary Outcome:

Information By: West China Hospital

Dates:
Date Received: August 10, 2011
Date Started: January 2004
Date Completion:
Last Updated: August 10, 2011
Last Verified: January 2011