Clinical Trial: Serum Calcium to Phosphorous Ratio (Ca/P) as a Simple, Inexpensive Screening Tool in the Diagnosis of Primary Hyperparathyroidism

Study Status: Completed
Recruit Status: Completed
Study Type: Observational

Official Title:

Brief Summary:

Background:

Primary hyperparathyroidism (PHPT) is often overlooked and underdiagnosed. At present the diagnosis of PHPT remains challenging and is based on serum calcium (Ca) and PTH.

As serum Ca and phosphorous (P) are inversely related in PHPT, the Ca/P ratio might be considered a good candidate tool in the diagnosis of PHPT.

AIM: The aim of this study is to investigate the diagnostic value of the Ca/P ratio in the diagnosis of PHPT.

Study design: Retrospective, observational, cross-sectional, case-control clinical trial will be carried out.

Biochemical measurements will include PTH, Vitamin D, serum Ca, P, albumin, and creatinine.


Detailed Summary:
Sponsor: Azienda USL Modena

Current Primary Outcome: Calcium [ Time Frame: Enrollment time ]

Assay performed at the moment of diagnosis


Original Primary Outcome: Same as current

Current Secondary Outcome:

  • Phosphorus [ Time Frame: Enrollment time ]
    Assay performed at the moment of diagnosis
  • Parathormone [ Time Frame: Enrollment time ]
    Assay performed at the moment of diagnosis
  • Creatinine [ Time Frame: Enrollment time ]
    Assay performed at the moment of diagnosis
  • Albumine [ Time Frame: Enrollment time ]
    Assay performed at the moment of diagnosis
  • Vitamin D [ Time Frame: Enrollment time ]
    Assay performed at the moment of diagnosis


Original Secondary Outcome: Same as current

Information By: Azienda USL Modena

Dates:
Date Received: January 18, 2017
Date Started: January 2011
Date Completion:
Last Updated: February 14, 2017
Last Verified: February 2017