Clinical Trial: Gene Expression in Hyperparathyroidism

Study Status: Recruiting
Recruit Status: Recruiting
Study Type: Observational

Official Title: Gene Expression in Hyperparathyroidism: Identifying Molecular Differences in MEN1 Patients Versus Young MEN1 Negative Patients

Brief Summary:

Objectives:

  1. To better define the differences in molecular genetics of parathyroid tumors in patients with MEN1, single gland parathyroid disease in patients less than 50 years old and single gland disease in patients greater than 50 years old.
  2. To better define the incidence of HRPT2 mutation in young patients with primary hyperparathyroidism and determine whether routine testing in these patients is indicated.

Detailed Summary: Patient charts will be reviewed to collect demographic data, pre-operative and post-operative clinical and laboratory data, operative reports, and pathology reports. Archived formalin-fixed paraffin-embedded (FFPE) tissue blocks from surgical specimens of patients will be stained for parafibromin to evaluate for HRPT2 mutations.
Sponsor: M.D. Anderson Cancer Center

Current Primary Outcome: Molecular Genetics of Parathyroid Tumors [ Time Frame: 10 years ]

RNA isolated from banked frozen tissues. cDNA microarray prepared using an Illumina array chip. Results analyzed using Ingenuity analysis software to detect 2-fold changes in gene expression. T-statistics used to determine significantly discriminating genes.


Original Primary Outcome: Same as current

Current Secondary Outcome: HRPT2 Mutations [ Time Frame: 10 years ]

Archived formalin-fixed paraffin-embedded (FFPE) tissue blocks from surgical specimens of patients stained for parafibromin to evaluate for HRPT2 mutations.


Original Secondary Outcome: Same as current

Information By: M.D. Anderson Cancer Center

Dates:
Date Received: February 3, 2017
Date Started: November 7, 2012
Date Completion: November 1, 2022
Last Updated: February 3, 2017
Last Verified: February 2017