Clinical Trial: Gene Expression in Hyperparathyroidism
Study Status: Recruiting
Recruit Status: Recruiting
Study Type: Observational
Official Title: Gene Expression in Hyperparathyroidism: Identifying Molecular Differences in MEN1 Patients Versus Young MEN1 Negative Patients
Brief Summary:
Objectives:
- To better define the differences in molecular genetics of parathyroid tumors in patients with MEN1, single gland parathyroid disease in patients less than 50 years old and single gland disease in patients greater than 50 years old.
- To better define the incidence of HRPT2 mutation in young patients with primary hyperparathyroidism and determine whether routine testing in these patients is indicated.
Detailed Summary: Patient charts will be reviewed to collect demographic data, pre-operative and post-operative clinical and laboratory data, operative reports, and pathology reports. Archived formalin-fixed paraffin-embedded (FFPE) tissue blocks from surgical specimens of patients will be stained for parafibromin to evaluate for HRPT2 mutations.
Sponsor: M.D. Anderson Cancer Center
Current Primary Outcome: Molecular Genetics of Parathyroid Tumors [ Time Frame: 10 years ]
Original Primary Outcome: Same as current
Current Secondary Outcome: HRPT2 Mutations [ Time Frame: 10 years ]
Original Secondary Outcome: Same as current
Information By: M.D. Anderson Cancer Center
Dates:
Date Received: February 3, 2017
Date Started: November 7, 2012
Date Completion: November 1, 2022
Last Updated: February 3, 2017
Last Verified: February 2017