Clinical Trial: Stereotactic Radiation to Decrease Pancreatic Secretions
Study Status: Completed
Recruit Status: Completed
Study Type: Interventional
Official Title: Utilization of Stereotactic Radiation in Patients With Pancreatic Fistula to Decrease Pancreatic Secretions
Brief Summary: Patients that have undergone pre-operative radiation for pancreatic carcinoma, that upon pathologic examination of the normal portion of the pancreatic gland that was in the radiation field showed acute and chronic changes in the pancreatic cells. The hypothesis for utilizing stereotactic radiation on pancreatic fistulae is that the treatment will decrease pancreatic secretions, thus decreasing autodigestion.
Detailed Summary: Stereotactic radiation for cancer has been utilized to successfully treat the head of the pancreas, which is generally a well-tolerated procedure with minimal complications. Upon further investigation under the microscope, after resection during a complex Whipple operation, it is noted that particularly the exocrine glandular tissue atrophied substantially. Based on this information, the hypothesis for utilizing stereotactic radiation on the remaining pancreas is production of a fibrosis of the pancreas and a decrease in the production of exocrine portion of the gland. The use of stereotactic radiation will be performed on individuals that are non-surgical candidates.
Sponsor: Carolinas Healthcare System
Current Primary Outcome: Decreased Secretions [ Time Frame: 1 year ]
Original Primary Outcome: Decreased Pancreatic Secretions [ Time Frame: 1 year ]
Current Secondary Outcome:
Original Secondary Outcome:
Information By: Carolinas Healthcare System
Dates:
Date Received: August 1, 2012
Date Started: July 2012
Date Completion:
Last Updated: February 14, 2014
Last Verified: February 2014
