Clinical Trial: Comparison of Levobupivacaine, Ropivacaine and Bupivacaine in Epidural Anaesthesia

Study Status: Completed
Recruit Status: Completed
Study Type: Interventional

Official Title: Comparative Evaluation of Newer Congeners i.e. Levobupivacaine and Ropivacaine With Bupivacaine, in Lumbar Epidural Anaesthesia for Hip Surgeries

Brief Summary: This study compares the clinical efficacy of newer local anaesthetic drugs Levobupivacaine and Ropivacaine with Bupivacaine in lumbar epidural anaesthesia for hip surgeries.

Detailed Summary:

Some of the most common day care surgeries are hip surgeries, in which local anaesthetic agents can be used via epidural route for both intra-op and post-op analgesia.

Among the drugs used nowadays are Lignocaine, Bupivacaine, Levobupivacaine and Ropivacaine.However Bupivacaine usage is not free from side effects.

The claimed benefits of both Levobupivacaine and Ropivacaine are reduced cardiac toxicity on overdose and more specific effects on sensory rather than motor nerve fibres.

Ropivacaine, an analog of Mepivacaine, is one of the long acting amide anaesthetic agent similar to Bupivacaine in chemical structure and anaesthetic function. It is a first enantiomer-specific compound, which has a reduced risk of cardio toxicity, neuro toxicity and rapid recovery of motor function. Levobupivacaine is the pure S (−)-enantiomer of Bupivacaine, and in recent year has emerged as a safer alternative for regional anaesthesia than its racemic parent.


Sponsor: Government Medical College, Haldwani

Current Primary Outcome: Onset of sensory block [ Time Frame: 30 minutes ]

Time to achieve sensory block up to tenth thoracic dermatome


Original Primary Outcome: Onset of sensory block [ Time Frame: 30 minutes ]

Time to achieve sensory block up to T 10 dermatome


Current Secondary Outcome:

  • Time for 2 segment regression of sensory block [ Time Frame: 90 minutes ]
    Time for regression of sensory block 2 segments lower than maximum blocked dermatome
  • Time to achieve maximum motor block [ Time Frame: 45 minutes ]
    Time to achieve motor block of modified Bromage score


Original Secondary Outcome: Same as current

Information By: Government Medical College, Haldwani

Dates:
Date Received: July 30, 2015
Date Started: December 2012
Date Completion:
Last Updated: July 31, 2015
Last Verified: July 2015