Clinical Trial: Ovarian Hyperstimulation Syndrome (OHSS) Prevention With Agonist
Study Status: Completed
Recruit Status: Completed
Study Type: Observational
Official Title: OHSS Prevention by GnRH-agonist Triggering of Final Oocyte Maturation and Cryoperservation of All Two-pronucleate Oocytes in Women Undergoing Stimulation for IVF With Gonadotrophins and GnRH-analogues
Brief Summary: The aim of the study is to explore the concept of GnRH-agonist triggering in combination with elective cryopreservation of all 2PN oocytes at larger scale in a pragmatic clinical setting. The question asked is: "Does GnRH-agonist triggering and cryopreservation work", in terms of efficacy and safety, when applied to a larger cohort of patients, and by a number of different centres with different clinical routines.
Detailed Summary:
Sponsor: University of Schleswig-Holstein
Current Primary Outcome: Cumulative ongoing pregnancy rate (10-12 GWs) per patient within 12 months [ Time Frame: 12 months after recruitment ]
Original Primary Outcome: Same as current
Current Secondary Outcome:
- ongoing pregnancy rate/frozen-thawed ET [ Time Frame: 12 months after recruitment ]
- Ongoing pregnancy rate/first frozen-thawed ET [ Time Frame: 12 months after recruitment ]
- time to pregnancy in weeks [ Time Frame: 12 months after recruitment ]
- incidence of OHSS III° [ Time Frame: 12 months after recruitment ]
- number of cumulus-oocyte-complexes [ Time Frame: 12 months after recruitment ]
- fertilization rate (number COCs/number of 2 PN oocytes [ Time Frame: 12 months after recruitment ]
- survival rate (number of vital embryos/number of frozen 2 PN oocytes [ Time Frame: 12 months after recruitment ]
Original Secondary Outcome: Same as current
Information By: University of Schleswig-Holstein
Dates:
Date Received: February 2, 2009
Date Started: May 2008
Date Completion:
Last Updated: June 13, 2012
Last Verified: June 2012
