Clinical Trial: Effects of Adrenergic Drugs on the Fluid Balance During Surgery
Study Status: Completed
Recruit Status: Completed
Study Type: Interventional
Official Title: The Effects of ß1-receptor Blockade and α1-adrenergic Agonist on the Kinetics of Lactated Ringer's Solution During Surgery
Brief Summary: The aim this study was to examine to what degree the slow turnover of lactated Ringer's solution during anesthesia and surgery can be prevented by infusing esmolol (a ß1-receptor blocker) or phenylephrine in patients undergoing laparoscopic gynecological surgery performed under intravenous anesthesia.
Detailed Summary:
INTRODUCTION The renal clearance of infused crystalloid fluid is very low during anaesthesia and surgery, but experiments in conscious sheep indicate that the renal fluid clearance might approach a normal rate when the adrenergic balance is modified.
METHODS Sixty females (mean age, 32 years) undergoing laparoscopic gynecological surgery were randomized to control group and received only the conventional anesthetic drugs and 20 ml/kg of lactated Ringer's over 30 min. The others were also given an infusion of 50 µg/kg/min of esmolol (beta1-receptor blocker) or 0.01 µg/kg/min of phenylephrine (alpha1-adrenergic agonist) over 3 hours. The distribution and elimination of infused fluid was studied by volume kinetic analysis based on urinary excretion and blood Hgb level.
Sponsor: Sodertalje Hospital
Current Primary Outcome: Urinary excretion [ Time Frame: 3 hours ]
Original Primary Outcome: Same as current
Current Secondary Outcome: Volume kinetics of lactated Ringer´s solution [ Time Frame: 3 hours ]
Original Secondary Outcome: Same as current
Information By: Sodertalje Hospital
Dates:
Date Received: September 6, 2011
Date Started: November 2008
Date Completion:
Last Updated: September 7, 2011
Last Verified: September 2011
