Clinical Trial: Clinical Assessment of Patients With High Bone Mass Due to Mutation in Lrp5
Study Status: Completed
Recruit Status: Completed
Study Type: Observational
Official Title: Clinical Assessment of Patients With High Bone Mass Due to Mutation in Low Density Lipoprotein l Receptor 5
Brief Summary: The aim of the study is to describe patients with a high bone mass phenotype due to a mutation in the low density lipoprotein l receptor 5 gene (LRP5) and compare them with age and sex matched controls. Moreover, bone density and microarchitecture as well as markers of bone metabolism are evaluated
Detailed Summary:
Cases and controls are closely matched on age and sex and evaluated cross-sectionally.
Dual x-ray absorptiometry (DXA) and high resolution peripheral quantitative computed tomography (HR-pQCT) are used in order to evaluate bone density as well as microarchitecture. Bone turnover markers and body composition are also measured.
Sponsor: Odense University Hospital
Current Primary Outcome: Bone microarchitecture as assessed by high resolution quantitative computed tomography (HR-pQCT) [ Time Frame: 12 weeks ]
Original Primary Outcome: Same as current
Current Secondary Outcome:
- Changes in bone turnover markers [ Time Frame: 12 weeks ]Markers of bone resorption and formation are investigated.
- Bone mineral density [ Time Frame: 12 weeks ]DXA is used to evaluate bone mineral density at total hip, spine, whole body and forearm.
Original Secondary Outcome: Same as current
Information By: Odense University Hospital
Dates:
Date Received: September 9, 2010
Date Started: January 2009
Date Completion:
Last Updated: September 9, 2010
Last Verified: August 2010