Clinical Trial: Characterization and Differential Diagnosis of Vertebral Osteomyelitis

Study Status: Completed
Recruit Status: Completed
Study Type: Observational

Official Title: Clinical Features, Microbiological-, Radiological Characteristics, and Differential Diagnosis of Vertebral Osteomyelitis

Brief Summary: Vertebral osteomyelitis is a uncommon disease that can lead to neurologic deficits if not diagnosed in time. The etiologies of vertebral osteomyelitis include pyogenic bacteria, M. tuberculosis, Brucella species, and fungus. The aim of this study is to describe the clinical features and microbiological/radiological characteristics of patients with vertebral osteomyelitis, and investigate the useful tips for the differential diagnosis of vertebral osteomyelitis.

Detailed Summary: Besides description of characteristics of patients with vertebral osteomyelitis, we also will investigate the usefulness of 16S rRNA gene sequence analysis of biopsy specimen. MRI findings during the antibiotic treatment will be monitored and compared for the differential diagnosis of meningitis.
Sponsor: Asan Medical Center

Current Primary Outcome: Identification of etiology of vertebral osteomyelitis [ Time Frame: within 6 weeks after the diagnosis of vertebral osteomyelitis ]

Original Primary Outcome: Same as current

Current Secondary Outcome: Unfavorable outcomes (death or permanent neurologic deficit) [ Time Frame: within 6 months after the diagnosis of vertebral osteomyelitis ]

Original Secondary Outcome: Same as current

Information By: Asan Medical Center

Dates:
Date Received: May 18, 2010
Date Started: May 2010
Date Completion:
Last Updated: February 24, 2014
Last Verified: September 2013