Clinical Trial: Chondromodulating Effect of Diacerein in Osteoarthritis of the Hip
Study Status: Completed
Recruit Status: Completed
Study Type: Interventional
Official Title: Evaluation of the CHOndromodulating Effect of DIAcerein in Osteoarthritis of the Hip. ECHODIAH.
Brief Summary:
We carried out a 3 years, randomized, double-blind, placebo-controlled, multicenter clinical trial in patients with hip osteoarthritis in order to:
- evaluate the ability of diacerein, an interleukin-1β inhibitor, to slow the progressive decrease in joint space width observed in patients with hip osteoarthritis
- to investigate the potential structure-modifying effect of diacerein in patients with hip osteoarthritis
This study compare also after ten years the percentage of patients in each treatment group who require a hip replacement surgery
Detailed Summary:
Sponsor: Laboratoires NEGMA
Current Primary Outcome: Joint space measurement
Original Primary Outcome: Same as current
Current Secondary Outcome:
- Requirement of hip replacement surgery after ten years
- Tolerability
Original Secondary Outcome: Same as current
Information By: Laboratoires NEGMA
Dates:
Date Received: March 22, 2007
Date Started: March 1993
Date Completion:
Last Updated: July 24, 2008
Last Verified: March 2007