Clinical Trial: Chondromodulating Effect of Diacerein in Osteoarthritis of the Hip

Study Status: Completed
Recruit Status: Completed
Study Type: Interventional

Official Title: Evaluation of the CHOndromodulating Effect of DIAcerein in Osteoarthritis of the Hip. ECHODIAH.

Brief Summary:

We carried out a 3 years, randomized, double-blind, placebo-controlled, multicenter clinical trial in patients with hip osteoarthritis in order to:

  • evaluate the ability of diacerein, an interleukin-1β inhibitor, to slow the progressive decrease in joint space width observed in patients with hip osteoarthritis
  • to investigate the potential structure-modifying effect of diacerein in patients with hip osteoarthritis

This study compare also after ten years the percentage of patients in each treatment group who require a hip replacement surgery


Detailed Summary:
Sponsor: Laboratoires NEGMA

Current Primary Outcome: Joint space measurement

Original Primary Outcome: Same as current

Current Secondary Outcome:

  • Requirement of hip replacement surgery after ten years
  • Tolerability


Original Secondary Outcome: Same as current

Information By: Laboratoires NEGMA

Dates:
Date Received: March 22, 2007
Date Started: March 1993
Date Completion:
Last Updated: July 24, 2008
Last Verified: March 2007