Clinical Trial: Exercise Therapy and Patient Education for Individuals With Hip Osteoarthritis of the Hip. A Case-Control Study

Study Status: Completed
Recruit Status: Completed
Study Type: Observational

Official Title: Evaluation of Function and Effect of Exercise in Patients With Osteoarthritis of the Hip.A Case-control Study.

Brief Summary:

To identify differences between patients with OA of the hip in an early stage and a healthy control group.

Hypothesis 1.1 There are significant differences between patients with OA of the hip in an early stage and a healthy control group in terms of functional capacity, biomechanical / kinematic variables, muscle strength and range of motion.

Osteoarthritis (OA) is by far the most prevalent joint disorder today. The knee and the hip are large joints to be targeted and is an important cause of pain and disability. In knee OA, it is shown that significant risk factors in developing the disease are quadriceps weakness, joint instability, and changes in joint loading. A few studies on hip OA have shown altered gait pattern, which affect joint loading, and one study has shown weakness in abductors, adductors and flexors around the hip. As joint loading and muscle weakness are important factors in the development in knee OA, it might as well be factors influencing OA in the hip. The purpose of this case-control studies was to compare hip OA patients to a healthy control group regarding biomechanical and clinical differences. Patients with hip pain, activity limitations (Harris Hip Score 60-95 p) and radiographically verified hip OA was included. The healthy control group will have a Harris Hip Score of 100 p. One hundred and ten patients and fifty controls will be asked to fill in questionnaires on pain, stiffness and physical function (WOMAC), quality-of-life (SF-36 v2), self-efficacy (Lorigue), and activity (PASE) in addition to perform 6-minute walk test, sub-maximal cardiovascular function, strength, and hip range of motion tests. Additionally, Qualisys Pro reflex 3D motion analysis system will be used during walking, one-leg standing, and raising from a chair on a sub-group of 40 patients and 20 controls.


Detailed Summary:

Aim 1 To identify differences between patients with OA of the hip in an early stage and a healthy control group.

Hypothesis 1.1 There are significant differences between patients with OA of the hip in an early stage and a healthy control group in terms of functional capacity, biomechanical / kinematic variables, muscle strength and range of motion.

Material and methods.

Design. A case-control study

Inclusion / exclusion criteria. Twenty-five patients diagnosed with unilateral or bilateral OA of the hip will be recruited from the Norwegian Sport Medicine Centre, Diakonhjemmet and from the Orthopaedic Centre, Ullevål University Hospital, Oslo, Norway. PPatients will also be recruited through ads in newspaper and brief information in national tv. Radiographiccally verified OA of the hip will be in accordance with Danielsson's criteria for minimal joint space. Patients will be excluded if they have a history of resent trauma or functional impairment to the lower limbs or diseases which might interfere with participation.

Control subjects will have no health problems and no injuries or functional impairment to the lower limbs and will be matched to the patients with OA of the hip by age and gender.

Outcome measures.

Background descriptive data, including anthropometrical (age, gender, height, weight) and sociodemographic information (marital status, social support, leisure time, sick-leave, physical activity, occupational background, co-morbidity, hip pain history, former treatment for hip pain / OA), and consumption of analgetics will be collected by questionnaire at inclusion
Sponsor: Ullevaal University Hospital

Current Primary Outcome: Western Ontario and McMaster Universities Osteoarthritis Index(WOMAC) [ Time Frame: Baseline ]

Original Primary Outcome: Western Ontario and McMaster Universities Osteoarthritis Index(WOMAC)

Current Secondary Outcome:

  • SF-36 (quality of life) [ Time Frame: Baseline ]
  • PASE (activity score) [ Time Frame: Baseline ]
  • muscle strength tests (Cybex 6000) [ Time Frame: Baseline ]
  • gait analysis (biomechanical analysis) [ Time Frame: Baseline ]
  • 6 minutes walking test [ Time Frame: Baseline ]
  • Åstrand's bike test [ Time Frame: Baseline ]
  • Range of Motion (goniometer) [ Time Frame: Baseline ]


Original Secondary Outcome:

  • SF-36 (quality of life)
  • PASE (activity score)
  • muscle strength tests (Cybex 6000)
  • gait analysis (biomechanical analysis)
  • 6 minutes walking test
  • Åstrand's bike test
  • Range of Motion (goniometer)


Information By: Oslo University Hospital

Dates:
Date Received: April 27, 2006
Date Started: April 2005
Date Completion:
Last Updated: March 1, 2016
Last Verified: May 2012