Clinical Trial: Protein Expression in Tumor Tissue Samples From Patients With Cancer of the Oropharynx

Study Status: Completed
Recruit Status: Completed
Study Type: Observational

Official Title: Protein Expression Profiles in Oropharyngeal Squamous Cell Carcinoma

Brief Summary:

RATIONALE: Studying the proteins expressed in samples of tumor tissue from patients with cancer may help doctors identify and learn more about biomarkers related to cancer. It may also help doctors plan better treatment for patients with cancer of the oropharynx.

PURPOSE: This laboratory study is looking at protein expression in tumor tissue samples from patients with cancer of the oropharynx.


Detailed Summary:

OBJECTIVES:

  • To investigate if some of the differences in gene expression are also reflected at the protein level.
  • To determine whether differences in gene expression that are also reflected at the protein level can be used to develop markers for early detection and disease surveillance.
  • To identify targets for therapy.

OUTLINE: Archived tumor tissue samples are analyzed for expression of standard immunohistological markers (e.g., p16, p53, and Ki-67) as well as expression of genes identified in a previous gene expression study. Protein expression data are tested for clinical and demographic correlates and compared with gene expression data.


Sponsor: Vanderbilt-Ingram Cancer Center

Current Primary Outcome:

  • Development of biomarkers for early detection or recurrence surveillance [ Time Frame: after 7 months of tissue collection ]
  • Identification of therapeutic targets and individualization of treatment based on the biology of squamous cell carcinoma of the oropharynx [ Time Frame: after 7months of tissue collection ]


Original Primary Outcome:

  • Development of biomarkers for early detection or recurrence surveillance
  • Identification of therapeutic targets and individualization of treatment based on the biology of squamous cell carcinoma of the oropharynx


Current Secondary Outcome:

Original Secondary Outcome:

Information By: Vanderbilt-Ingram Cancer Center

Dates:
Date Received: May 9, 2009
Date Started: May 2006
Date Completion:
Last Updated: March 29, 2013
Last Verified: March 2013