Clinical Trial: Is the WHO Recommended Dose of Pralidoxime Effective in the Treatment of Organophosphorus Poisoning?

Study Status: Completed
Recruit Status: Completed
Study Type: Interventional

Official Title: Study Effect of WHO Recommended Dose of Pralidoxime in the Treatment of Organophosphorus Poisoning

Brief Summary: To evaluate the effectiveness of Pralidoxime, a drug used for treatment of pesticide poisoning (Organophosphorous poisonings)

Detailed Summary: The present study was designed to critically analyze the role of pralidoxime in patients with moderate to severe poisoning by dividing them into two comparable groups in all aspects and using WHO recommended dose of pralidoxime (30mg/kg bolus I.V over 20 min followed by 8mg/kg/hr continuous infusion). This dose and continuous infusion protocol is more likely to maintain adequate blood concentrations of pralidoxime throughout 24 hours and thus would avoid any failures in effectiveness of pralidoxime because of inconsistent blood levels.
Sponsor: Sheri Kashmir Institute of Medical Sciences

Current Primary Outcome: mortality rate [ Time Frame: upto one year ]

Original Primary Outcome: Same as current

Current Secondary Outcome: duration of ventilation [ Time Frame: upto one year ]

Original Secondary Outcome: Same as current

Information By: Sheri Kashmir Institute of Medical Sciences

Dates:
Date Received: January 9, 2014
Date Started: April 2012
Date Completion:
Last Updated: January 16, 2014
Last Verified: January 2014