Clinical Trial: The Prospective Study of Standard Treatment of Graves Disease Iodine 131 and Prevention of Adverse Reactions

Study Status: Active, not recruiting
Recruit Status: Unknown status
Study Type: Interventional

Official Title: "5010 Clinical Research Programme"of Sun Yat-sen University

Brief Summary: Iodine 131 (131I） treatment on Graves disease and Graves ophthalmopathy relationship has always been the focus of debate. Majority view is that the current treatment does not increase 131I Graves ophthalmopathy, therefore,Graves disease associated with exophthalmos is not a contraindication of 131I treatment. While treatment with corticosteroids, a timely corrective measures to be effective in preventing Graves ophthalmopathy adverse effects. But the merger with severe proptosis in patients with Graves , especially infiltrative exophthalmos , the application of 131I treatment will induce or aggravate not yet reached consensus, so, the 131I treatment is still very careful , mainly due to plaque prospective study and visual assessment is not lack of uniform standards, and a variety of factors (including smoking, work status, and 131I treatment of thyroid doses, etc.) may also interfere or influence the ultimate effect of 131I on the Graves ophthalmopathy. In the view of this situation Graves disease patients with Graves ophthalmopathy could be 131I treatment or not, how to dose adjustments, and the use of which required treatment with systemic issues such as research, explore treatment exophthalmos reduction and mitigation of increased proptosis reasonable treatment of symptoms. To further promote the standardization of 131I treatment of Graves disease on basis.

Detailed Summary: no more description
Sponsor: Sun Yat-sen University

Current Primary Outcome: The rate of Hypothyroidism after Iodine 131 treatment [ Time Frame: one year ]

Original Primary Outcome: Same as current

Current Secondary Outcome: The side effect to Infiltrative exophthalmos after Iodine 131 treatment [ Time Frame: one year ]

Original Secondary Outcome: Same as current

Information By: Sun Yat-sen University

Dates:
Date Received: September 15, 2010
Date Started: July 2007
Date Completion: December 2016
Last Updated: May 22, 2015
Last Verified: May 2015