Clinical Trial: Taste And Smell TEsting in End Stage Renal Disease

Study Status: Recruiting
Recruit Status: Recruiting
Study Type: Observational

Official Title: TASTE ESRD: Taste And Smell TEsting in End Stage Renal Disease

Brief Summary: Malnutrition is an important complication of advanced kidney disease and impairment in smell and taste may affect nutritional status. This study will examine the association between impairment in smell and taste and nutritional and functional markers among patients with end stage renal disease, as well as risk factors for smell and taste impairment.

Detailed Summary:

People with advanced chronic kidney disease (CKD) are at risk for malnutrition, which is associated with significantly increased mortality. Impairments in olfaction and taste are under-recognized and under-addressed symptoms that affect this population. Olfaction and taste influence appetite and nutritional status and represent a unique target for study and intervention. Small cross-sectional studies have shown a higher prevalence of olfactory (up to 56%) and taste disturbances (up to 35%) among patients with CKD compared with the general population, but little is known about longitudinal change in olfaction and taste in this population. Additionally, there is a lack of understanding about why these sensory disturbances more commonly occur in people with CKD, although there is speculation that uremia may contribute.

This information gained from this study will address these gaps in knowledge by studying longitudinal changes in olfaction and taste and their associations with concurrent and future nutritional and functional status. Additionally this study will attempt to identify potentially modifiable risk factors associated with olfactory and taste impairment.


Sponsor: Beth Israel Deaconess Medical Center

Current Primary Outcome: change in lean body mass [ Time Frame: from 6 months to 1 year ]

lean body mass will be determined by dual-energy X-ray absorptiometry scan


Original Primary Outcome: Same as current

Current Secondary Outcome:

  • change in hand grip strength [ Time Frame: from 6 months to 1 year ]
    measured by dynamometer
  • change in the physical function score [ Time Frame: from 6 months to 1 year ]
    measured by Standard-Form 36 version 2


Original Secondary Outcome: Same as current

Information By: Beth Israel Deaconess Medical Center

Dates:
Date Received: February 2, 2017
Date Started: February 15, 2017
Date Completion: February 6, 2021
Last Updated: March 16, 2017
Last Verified: March 2017